–{ Publications in English

  1. Familial proinsulinemia: a rare disorder of insulin biosynthesis. in Proinsulin, Insulin, C-peptide. ed. by S. Baba, T. Kaneko, and N. Yanaihara. p262-269. Elsvier North-Holland. 1979 [Kanazawa, Y., M. Hayashi, M. Ikeuchi, M. Kasuga, Y. Oka, H. Sato, K. Hiramatsu, and K. Kosaka.]
  2. Functional organizatio of I-J subregion gene products on T cell hybridomas. Biochemical Characterization of Lymphokines, p577-582, Academic Press. 1980 [Taniguchi, M., I. Takei, T. Saito, K. Hiramatsu, and T. Tada.]
  3. Ia antigen of T cell factors produced by hybridomas. Immunology of the Major Histocompatibility Complex, p69-71, Basel. 1981 [Tada, T., M. Taniguchi, K. Okumura, K. Hayakawa, K. Hiramatsu, and G. Suzuki.]
  4. Unique T cell Ia antigen expressed on a hybrid cell line producing antigen-specific augmenting T cell factor. J. Immunol. 127:1118-1122. 1981 [Hiramatsu, K., S. Miyatani, M. Kim, S. Yamada, K. Okumura, and T. Tada.]
  5. Monoclonal antibodies detecting a unique set of I region gene products expressed only on mature functional T cells. Nature, 296:666-668. 1982 [Hiramatsu, K., A. Ochi, S. Miyatani, A. Segawa, and T. Tada.]
  6. Monoclonal T cell Factors: antigen structure, fuctions and genetics. Immunopathology VIII, p149-162, Academic Press. 1982 [Tada, T., G. Suzuki, K. Hiramatsu, K. Hayakawa, and M. Taniguchi.]
  7. Some comments on the antigen-receptors expressed on functional T cell hybridomas. Lymphokines V p119-128, Academic Press. 1982 [Tada, T., G. Suzuki, and K. Hiramatsu.]
  8. I-A homologous antigen on human lymphocytes detected by a monoclonal antibody. Immunogenetics 17:101-108. 1983 [Yamamoto, K., Y. Kumagai, K. Hiramatsu, K. Okumura, and T. Tada.]
  9. Structural analysis of antigen-specific Ia-bearing regulatory T cell factors: gel electrophoretic anlysis of the antigen-specific augmenting T cell factor. Proc. Natl. Acad. Sci. U. S. A. 80:6336-6340. 1983 [Miyatani, S., K. Hiramatsu, P. B. Nakajima, F. L. Owen, and T. Tada.]
  10. IgVH and MHC-restricted regulatory circuit in the immune response. Immunoregulation 81, p1-11, Plenum Press. 1983 [Tada, T., G. Suzuki, R. Abe, Y. Kumagai, K. Hiramatsu, and S. Miyatani.]
  11. T-T cell interactions in the regulation of the antibody response: The role of I region gene products on T cells. Immunopharmacology II, p301-306, Pergamon Press. 1983 [Tada, T., K. Hiramatsu, M. Nonaka, S. Miyatani, and R. Abe.]
  12. Mode of transmission of human T cell leukemia virus type I (HTLV-I) in a human promyelocytic leukemia HL60 cell. J. Cancer 37:601-606. 1986 [Hiramatsu, K., M. Masuda, and H. Yoshikura.]
  13. Frequent partial deletion of human T cell leukemia virus type I (HTLV-I) proviruses in experimental transmission: Pattern and possible implication. J. Virol. 58:508-512. 1986 [Hiramatsu, K., and H. Yoshikura.]
  14. Molecular cloning of the closed circular prvirus of human T cell leukemia virus type I: A new open reading frame in the gag-pol regions J. general Virol. 68:213-218. 1987 [Hiramatsu, k., J. Nishida, A. Naito, and H. Yoshikura.]
  15. Epigenetical control and re-integration of extra-chromosomal proviral DNA in HL60 cells chronically infected with HTLV-I. J. general Virol. 69:651-658. 1988 [Hiramatsu, K., R. Yonemoto, and H. Yoshikura.]
  16. Molecular cloning and complete nucleotide sequence of the genome of Japanese encephalitis virus Beijing-1 strain. Virus Genes 1(3):305-317. 1988 [Hashimoto, H., A. Nomoto, K. Watanabe, T. Mori, T. Takezawa, C. Aizawa, T. Takegami, and K. Hiramatsu.]
  17. Identification of genomic fragments determining serotype specificities of Vibrio cholerae O1. Biochem. Biophys. Res. Comm. 175:679-684. 1991 [. Ito, T., Y. Ohshita, T. Nakamoto, K., Hiramatsu, and T. Yokota.]
  18. Identification and nucleotide sequence determination of the gene responsible for Ogawa serotype specificity of V. cholerae O1. FEBS Biological Lett. 286:1-2,159-162. 1991 [Ito, T., Y. Ohshita, K. Hiramatsu, and T. Yokota.]
  19. Mutations in the rfbT gene are responsible for the Ogawa to Inaba serotype conversion in Vibrio cholerae O1. Microb. Immun. 37(4):281-288. 1993 [Ito, T., K. Hiramatsu, Y. Ohshita, and T. Yokota.]
  20. Identification of a novel sugar, 2-O-methyl-4-amino-4,6-dideoxy mannose in the lipopolysaccharide of V. cholerae O1 serotype Ogawa. Journal [ Authors ]
  21. Interleukin 6 / B cell stimulating factor-II is expressed and released by normal and transformed human bronchial epithelial cells. Biochem. Biophys. Biochem. Biophys. Res. Comm. 187:596-602. 1992 [Takizawa, H., T. Ohtoshi, K. Ohta, S. Hirohata, M. Yamaguchi, N. Suzuki, T. Ueda, A. Ishii, G. Shindoh, T. Oka, K. Hiramatsu, and K. Ito.]
  22. Growth inhibition of human lung cancer cell lines by interleukin 6: A possible role in tumor growth via an autocrine mechanism. Cancer Res.53:4175-4181. 1993 [Takizawa, H., T. Ohtoshi, K. Ohta, N. Yamashita, S. Hirohata, K. Hirai, K. Hiramatsu, and K. Ito.]
  23. Erythromycin suppresses interleukin 6 expression by human bronchial epithelial cells: A potential mechanism of its anti-inflammatory action. Biophys. Res. Comm. 210:781-786. 1995 [Takizawa, H., M. Desaki, T. Ohtoshi, T. Kikutani, H. Okazaki, M. Sato, N. Akiyama, S. Shoji, K. Hiramatsu, and K. Ito.]
  24. Increase in T cells expressing the g/d receptor and CD4+CD8+double positive T cells in primary immunodeficiency complicated by HTLV-I infection. Blood 80(12):3253- 3255. 1992 [Furukawa, S., K. Sasai, T. Matsubara, K. Yabuta, K. Hiramatsu,T. Yamamoto, T. Shirai, K. Okumura.]
  25. Elevated anti-alginate serum titer in the acute cholangitis of the patients having biliary stones lodged by Pseudomonas aeruginosa. J. Infect. Chemother. 1:147-151. 1995 [Uetera, Y., K. Hiramatsu, T. Yokota, K. Sato, and M. Ogawa.]
  26. On the instability of methicillin-resistance in methicillin-resistant Staphylococcus aureus (MRSA) Recent Advances in Chemotherapy 662:1-2. 1989 [Hiramatsu, K., E. Suzuki, H. Takayama, Y. Katayama, and T. Yokota.]
  27. Role of penicillinase-plasmids in the stability of the mecA gene in methicillin- and cephem-resistant Staphylococcus aureus.. Antimicrob. Agents Chemother 34(4): 600-604. 1990 [Hiramatsu, K., E. Suzuki, H. Takayama, Y. Katayama, and T. Yokota.]
  28. Gel electrophoretic analysis of penicillin-binding proteins of coagulase-negative staphylococcus. FEMS Microbiol. Lett.72:51-54. 1990 [Kanda, K., K. Hiramatsu, and T. Yokota.]
  29. Identification of a methicillin-resistant strain of S. caprae from a human clinical specimen. Antimicrob. Agents Chemother. 35:174-176. 1991 [Kanda, K., E. Suzuki, K. Hiramatsu, T. Oguri, H. Miura, T. Ezaki, and T. Yokota.]
  30. A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus. Biochem. Biophys. Res. Comm. 172:1028-1034. 1991 [Ohshita, Y., K. Hiramatsu, and T. Yokota.]
  31. Southrn hybridization analysis of the mecA deletion from methicillin-resistant Staphylococcus aureus. Biochem. Biophys. Res. Comm. 176:1319-1325. 1991 [Wada, A., Y. Katayama, K. Hiramatsu, and T. Yokota.]
  32. Survey of methicillin-resistant clinical strains of coagulase-negative Staphylococcus for mecA gene distribution. Antimicrob. Agents Chemother. 36:429-434. 1992 [Suzuki, E., K. Hiramatsu, and T. Yokota.]
  33. The role of IS431 in the deletion of mecA from the chromosome of Staphylococcus aureus. . Recent Advances in Chemotherapy. 1992 [Wada, A., E. Suzuki, K. Hiramatsu, and T. Yokota.]
  34. Analysis of borderline-resistant strains of methicillin-resistant Staphylococcus aureus using polymerase chain reaction. Microbiol. & Immunol. 36:445-453. 1992 [Hiramatsu, K., Kihara, and T. Yokota.]
  35. Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus. FEBS Lett. 298:133-136. 1992 [Hiramatsu, K., K. Asada, E. Suzuki, K. Okonogi, and T. Yokota.]
  36. Characterization of methicillin-resistant Staphylococcus aureus associated with nosocomial infections in the university hospital, Kuala Lumpur. . J. Hosp. Infect. 21:15-28. 1992 [Yasmin, A., K. Hiramatsu, and T. Yokota.]
  37. Distribution of the novel genes, mecR1 and mecI, in clinical strains of methicillin-resistant staphylococci. Antimicrob. Agents Chemother. 37:1219-1226. 1993 [Suzuki, E., J.F. Richardson, and K. Hiramatsu.]
  38. Molecular cloning and mapping of 16S-23S ribosomal RNA gene complexes in Staphylococcus aureus J. Bacteriol. 175:7483 -7487. 1993 [Wada A, Ohta H, Kulthanan K, Hiramatsu K ]
  39. Sequential acquisition of new-quinolone resistance by methicillin-resistant and -susceptible Staphylococcus aureus. Antimicrob. Agents Chemother. 37:2278-2284. 1993 [Hori, S., Y. Ohshita, Y. Utsui, and K. Hiramatsu.]
  40. Potent in vitro bactericidal activity of polymyxin B against methicillin-resistant Staphylococcus aureus (MRSA). ) Microb. & Immunol. 37:853-859. 1993 [Yoshida, T., and K. Hiramatsu.]
  41. Pulsed-field gel electrophoresis (PFGE) of chromosomal DNA of methicillin-resistant Staphylococcus aureus associated with nosocomial infections. Malaysian J. Pathology. 16(2):151-156. 1994 [Yasmin Abu Hanifah, and K. Hiramatsu.]
  42. Comparative study of in vitro antimicrobial activity of a newly synthesized quinolone, AM-1155, and other 4-quinolone antibiotics. Recent Advances in Chemother. pp282-283. 1994 [Suzuki, E., T. Yokota, and K. Hiramatsu.]
  43. Methicillin resistance regulation of the prototype MRSA strain. Staphylococci and Staphylococcal infections pp191-193. Ed. by R. Moellby, J.-I. Flock, C.E. Nord and B. Christensson. Gustav Fischer Verlag. 1994 [Hiramatsu, K., K. Asada, E. Suzuki, and T. Yokota.]
  44. Sequential acquisition of new-quinolone resistance by methicillin-resistant and susceptible Staphylococcus aureus p256-258. In R. Moellby, J.-I. Flock, C.E. Nord and B. Christensson (ed.) Staphylococci and Staphylococcal infections.. Gustav Fischer Verlag. 1994 [Hori, S., K. Hiramatsu, Y. Utsui, and T. Yokota.]
  45. A retrospective study on methicillin-resistant Staphylococcus aureus clinical strains in Tokyo University Hospital. J. Infect. Chemother. 1: 42-51. 1995 [Tanaka, T., K. Okuzumi, A. Iwamoto, and K. Hiramatsu.]
  46. TOC-39, a novel parenteral broad-spectrum cephalosporin with an excellent activity against methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 39:1120-1126. 1995 [Hanaki, H., H. Akagi, Y. Masaru, T. Otani, A. Hyodo, and K. Hiramatsu.]
  47. Evolution and resistance expression of MRSA; evaluation of beta-Lactam antibiotics against a set of isogenic strains withdifferent types of phenotypic expression. Acta Biochimica Polonica 42: 517-524. 1995 [Asada, K., Y. Inaba, E. Tateda-Suzuki, K. Kuwahara-Arai, T. Ito, and K. Hiramatsu.]
  48. MRSA: World-Wide Epidemiology and Resistance Mechanism. in ASEAN-JAPAN Seminar and Workshop on Hospital Infection Yun-Fong Ngeow and K. Hiramatsu, p25-32. 1995 [Kondo N., T. Ito, E. Tateda-Suzuki, T. Yoshida, Y. Abu Hanifah and K. Hiramatsu.]
  49. Structure-activity relationships of cephalosporin derivatives against methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. J. Antibiot. 49(4):402-404. 1996 [Hanaki, H., H. Akagi, S. Nomura, N. Unemi, and K. Hiramatsu]
  50. The grlA mutation in norfloxacin-resistant first-step mutants and clinical isolates of Staphylococcus aureus. J. Infect. Chemother. 2(2):98-101. 1996 [Fukuda, H., S. Hori, and K. Hiramatsu.]
  51. Suppression of methicillin resistance in a mecA-containing pre-methicillin-resistant Staphylococcus aureus strain is caused by the mecI-mediated repression of PBP2' production. Antimicrob. Agents Chemother 40:2680-2685. 1996 [Kuwahara-Arai, K., N. Kondo, S. Hori, and E. Tateda-Suzuki.]
  52. Structure-activity relationships between linkage style at the C-3 position and nuclear analogues of C(7)-hydroxyiminoaminothiazol cephalosporins against methicillin-resistant Staphylococcus aureus. J. Infect. Chemother. 2(3):143-147. 1996 [Hanaki, H., H. Akagi, T. Ohtani, and K. Hiramatsu.]
  53. Lipopolysaccharides of Escherichia coli K122 strains that express cloned genes for the Ogawa and Inaba antigens of Vibrio cholerae O1: Identification of O-antigenic factors. Microbiol. Immunol. 40:621-626. 1996 [Hisatsune, K., S. Kondo, T. Ito, and K. Hiramatsu.]
  54. Methicillin-resistantant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J. Ant. Chemother. 40:135-136. 1997 [Hiramatsu, K., H. Hanaki, T. Ino, K. Yabuta, T. Oguri, and F.C. Tenover.]
  55. Reduced susceptibility of Staphylococcus aureus to vancomycin - Japan, 1996. Morbidity and Mortality Weekly Report 46:624-626. 1997 [Hiramatsu, K., Hospital Infections Program, National Center for Infectious Diseases, CDC.]
  56. Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet 6;350(9092):1670-3. 1997 (with commentary p1644) [Hiramatsu K, Aritaka N, Hanaki H, Kawasaki S, Hosoda Y, Hori S, Fukuchi Y, Kobayashi I ]
  57. Combined use of ribotyping, PFGE typing, and IS431 typing in the discrimination of nosocomial strains of metheicillin-resistant Staphylococcus aureus Microbiol. Immunol. 41(9), 687-695. 1997 [Yoshida, T., N. Kondo, Yasmin Abu Hanifah, and K. Hiramatsu.]
  58. The Emergence of Staphylococcus aureus With Reduced Susceptibility to Vancomycin in Japan. Am. J. Med. 104(5A):7S-10S. 1998 [Hiramatsu, K.]
  59. In-vitro activity of DU-6859a against methicillin-resistant Staphylococcus aureus isolates with reduced susceptibility to vancomycin. Antimicrob. Chemother. 42: 552-553. 1998 [Tanaka, M., N. Wada, S. Mori-Kurosaka, M. Chiba, K. Sato, and K. Hiramatsu.]
  60. Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50. Journal of Antimicrobial Chemotherapy 42: 199-209. 1998 [Hanaki, H., Kuwahara-Arai, K., Boyle-Vavra, S., Daum, R.S., Labischinski, H. & Hiramatsu, K.]
  61. Increase in the deamidated muropeptides in the peptidoglycan of vancomycin-resistant Staphylococcus aureus (VRSA) strain Mu50. . Journal of Antimicrobial Chemotherapy 42:315-320. 1998 [Hanaki, H., Labischinski, Y. Inaba, H., Kondo, N. & Hiramatsu, K.]
  62. Antibacterial activity of gatifloxacin, a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicribial Agents and Chemotherapy 42:1917-1922. 1998 [Fukuda, H., Hori, S. & Hiramatsu, K.]
  63. Characterization of staphylococci with reduced susceptibility to vancomycin and other glycopeptides. Journal of Clinical Microbiology 36:1020-1027. 1998 [Tenover, F.C., Lancaster, M.V., Hill, B.C., Steward, C.D., Stocker, S.A., Hancock, G.A., O'Hara, C.M., Clark, N.C. & Hiramatsu, K.]
  64. Acquisition of methicillin resistance and progression of multiantibiotic resistance in methicillin-resistant Staphylococcus aureus.Yonsei Med J 1998 Dec;39(6):526-33
  65. Primary targets of fluoroquinolones in Streptococcus pneumoniae. Antimicrob Agents Chemother1998 Feb. 43(2) 410-2 [Fukuda, H., and K. Hiramatsu.]
  66. Postoperative toxic shock syndrome caused by a highly virulent methicillin-resistant Staphylococcus aureus strain. . Scandinavian J. of Infectious Diseases. 31(2):208-209, 1999 [Cui, L-Z(LongZhu)., Kasegawa, H., Murakami, Y., Hanaki, H., and K. Hiramatsu.]
  67. Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315.Antimicrob Agents Chemother 1999 June;43(6):1449-58 [Ito T, Katayama Y, Hiramatsu K]
  68. DNA vaccination by mecA sequence evokes an antibacterial immune response against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother Dec;44(6):767-74 1999 [Ohwada A, Sekiya M, Arai KK, Nagaoka I, Hori S, Tominaga S, Hiramatsu K, Fukuchi Y]
  69. Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method. Biochem Biophys Res Commun 2000 Mar 16;269(2):485-90 [Kuroda M, Kuwahara-Arai K, Hiramatsu K]
  70. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother. Jun;44(6):1549-55 2000 [Katayama Y, Ito T, Hiramatsu K]
  71. Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50.Antimicrob Agents Chemother. Sep;44(9):2276-2285 2000[Longzhu Cui, Hiroko Murakami, Kyoko Kuwahara-Arai, Hideaki Hanaki, and Keiichi Hiramatsu]
  72. Vancomycin-intermediate Staphylococcus aureus in Korea. .J Clin Microbiol 2000 Oct;38(10):3879-81[Kim MN, Pai CH, Woo JH, Ryu JS, Hiramatsu K.]
  73. Early diagnosis of postoperative infection: assessment of whole blood chemiluminescence.Surg Today 2000;30(4):309-18[Fujisawa M, Kojima K, Beppu T, Futagawa S, Kuwahara K, Hiramatsu K.]
  74. Survey and properties of methicillin-resistnt Staphylococcus aureus(MRSA) in an urban living environment.J. Home Econ Jpn, 51:215-221 2000[Yamada C, Katayama Y, Murata M, Homma S, Hanaki H, Hiramatsu K]
  75. Novel cephalosporins 1. Synthesis of 3-benzothiopyranylthiovinyl cephalosporins and antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. J Antibiot (Tokyo) 2000 May;53(5):546-50 [Yamazaki H, Tsuchida Y, Satoh H, Kawashima S, Hanaki H, Hiramatsu K.]
  76. Novel cephalosporins 2. Synthesis of 3-heterocyclic-fused thiopyranylthiovinyl cephalosporins and antibacterial activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. J Antibiot (Tokyo) 2000 May;53(5):551-5 [Yamazaki H, Tsuchida Y, Satoh H, Kawashima S, Hanaki H, Hiramatsu K.]
  77. Improvement of Water-Soluble Cephalosporin Derivatives Having Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus. Chemotherapy 2001 May;47(3):170-176[Hanaki H, Nomura S, Akagi H, Hiramatsu K.]
  78. Vancomycin-resistant Staphylococcus aureus occurs in South Africa.S Afr Med J. 2000 Nov;90(11):1108-9[Ferraz V, Duse AG, Kassel M, Black AD, Ito T, Hiramatsu K.]
  79. First report of methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin in Thailand.J Clin Microbiol 2001 Feb;39(2):591-5 [Trakulsomboon S, Danchaivijitr S, Rongrungruang Y, Dhiraputra C, Susaemgrat W, Ito T, Hiramatsu K.]
  80. Combination Effect of Vancomycin and beta-Lactams against a Staphylococcus aureus Strain, Mu3, with Heterogeneous Resistance to Vancomycin. Antimicrob Agents Chemother 2001 Apr;45(4):1292-4 [Aritaka N, Hanaki H, Cui L, Hiramatsu K.]
  81. Eagle-type methicillin resistance: new phenotype of high methicillin resistance under mec regulator gene control. Antimicrob Agents Chemother 2001 Mar;45(3):815-24 [Kondo N, Kuwahara-Arai K, Kuroda-Murakami H, Tateda-Suzuki E, Hiramatsu K.]
  82. Structural Comparison of Three Types of Staphylococcal Cassette Chromosome mec Integrated in the Chromosome in Methicillin-Resistant Staphylococcus aureus.Antimicrob Agents Chemother 2001 May;45(5):1323-36 [Ito T, Katayama Y, Asada K, Mori N, Tsutsumimoto K, Tiensasitorn C, Hiramatsu K.]
  83. Genetic Organization of the Chromosome Region Surrounding mecA in Clinical Staphylococcal Strains: Role of IS431-Mediated mecI Deletion in Expression of Resistance in mecA-Carrying, Low-Level Methicillin- Resistant Staphylococcus haemolyticus.Antimicrob Agents Chemother 2001 Jul;45(7):1955-63 [Katayama Y, Ito T, Hiramatsu K.]
  84. Whole genome sequencing of meticillin-resistant Staphylococcus aureus.Lancet 2001 Apr 21;357(9264):1225-40 [Kuroda M, Ohta T, Uchiyama I, Baba T, Yuzawa H, Kobayashi I, Cui L, Oguchi A, Aoki K, Nagai Y, Lian J, Ito T, Kanamori M, Matsumaru H, Maruyama A, Murakami H, Hosoyama A, Mizutani-Ui Y, Takahashi NK, Sawano T, Inoue R, Kaito C, Sekimizu K, Hirakawa H, Kuhara S, Goto S, Yabuzaki J, Kanehisa M, Yamashita A, Oshima K, Furuya K, Yoshino C, Shiba T, Hattori M, Ogasawara N, Hayashi H, Hiramatsu K.]
  85. Novel Type of Staphylococcal Cassette Chromosome mec Identified in Community-Acquired Methicillin-Resistant Staphylococcus aureus Strains.Antimicrob Agents Chemother. 2002 Apr;46(4):1147-52. [Ma XX, Ito T, Tiensasitorn C, Jamklang M, Chongtrakool P, Boyle-Vavra S, Daum RS, Hiramatsu K.]
  86. Genome and virulence determinants of high virulence community-acquired MRSA.Lancet. 2002 May 25;359(9320):1819-27. [Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K.]
  87. Nosocomial spread of a Staphylococcus capitis strain with heteroresistance to vancomycin in a neonatal intensive care unit.J Clin Microbiol. 2002 Jul;40(7):2520-5. [Van Der Zwet WC, Debets-Ossenkopp YJ, Reinders E, Kapi M, Savelkoul PH, Van Elburg RM, Hiramatsu K, Vandenbroucke-Grauls CM.]
  88. A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds.J Infect Dis. 2002 Nov 1;186(9):1344-7. Epub 2002 Oct 03. [Daum RS, Ito T, Hiramatsu K, Hussain F, Mongkolrattanothai K, Jamklang M, Boyle-Vavra S.]
  89. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community.J Clin Microbiol. 2002 Nov;40(11):4289-94. [Okuma K, Iwakawa K, Turnidge JD, Grubb WB, Bell JM, O'Brien FG, Coombs GW, Pearman JW, Tenover FC, Kapi M, Tiensasitorn C, Ito T, Hiramatsu K.]
  90. Enumeration of Legionella CFU by colony hybridization using specific DNA probes.Appl Environ Microbiol. 2002 Dec;68(12):6466-70. [Satoh W, Nakata M, Yamamoto H, Ezaki T, Hiramatsu K.]
  91. Emergence of vancomycin resistance during therapy against methicillin-resistant Staphylococcus aureus in a burn patient--importance of low-level resistance to vancomycin.Int J Infect Dis. 2002 Dec;6(4):302-8. [Haraga I, Nomura S, Fukamachi S, Ohjimi H, Hanaki H, Hiramatsu K, Nagayama A.]
  92. Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus.J Clin Microbiol. 2003 Jan;41(1):5-14. [Cui L, Ma X, Sato K, Okuma K, Tenover FC, Mamizuka EM, Gemmell CG, Kim MN, Ploy MC, El-Solh N, Ferraz V, Hiramatsu K.]
  93. Physiological and molecular analysis of a mecA-negative Staphylococcus aureus clinical strain that expresses heterogeneous methicillin resistance.J Antimicrob Chemother. 2003 Feb;51(2):247-55. [Yoshida R, Kuwahara-Arai K, Baba T, Cui L, Richardson JF, Hiramatsu K.]
  94. Identification in methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec of methicillin-resistant Staphylococcus aureus.J Bacteriol. 2003 May;185(9):2711-22. [Katayama Y, Takeuchi F, Ito T, Ma XX, Ui-Mizutani Y, Kobayashi I, Hiramatsu K.]
  95. Antibacterial activity of 2,4-diacetylphloroglucinol (DAPG) produced by Pseudomonas sp. AMSN isolated from a marine alga, against vancomycin-resistant Staphylococcus aureus Int J Antimicrob Agents. 2003 Nov;22(5):545-7. [Isnansetyo, A., Cui, L., Hiramatsu, K., and Kamei, Y. ]
  96. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.Mol Microbiol. 2003 Aug;49(3):807-21. [Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.]
  97. Nucleotide substitutions in Staphylococcus aureus strains, Mu50, Mu3, and N315 DNA Res. 2004 Feb 29;11(1):51-6. [ Ohta T, Hirakawa H, Morikawa K, Maruyama A, Inose Y, Yamashita A, Oshima K, Kuroda M, Hattori M, Hiramatsu K, Kuhara S, Hayashi H.]
  98. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob Agents Chemother. 2004 Jul;48(7):2637-51 [ Ito T, Ma XX, Takeuchi F, Okuma K, Yuzawa H, Hiramatsu K. ]
    [CLICK HERE] to see [ESI Special Topics, October 2005] This paper has been selected for "Fast Breaking Papers" of that had the highest percentage increase in citations in ISI Essential Science Indicators from the second bimonthly period of 2005 to the third bimonthly period of 2005.
  99. Vancomycin heteroresistance in methicillin-resistant Staphylococcus aureus, Taiwan. Emerg Infect Dis. 2004 Sep;10(9):1702-4. [ Wang JL, Tseng SP, Hsueh PR, Hiramatsu K. ]
  100. Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin. Antimicrob Agents Chemother. 2004 Dec;48(12):4926-8. [ Song JH, Hiramatsu K, Suh JY, Ko KS, Ito T, Kapi M, Kiem S, Kim YS, Oh WS, Peck KR, Lee NY; Asian Network for Surveillance of Resistant Pathogens Study Group.]
  101. Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions. Inflamm Res. 2005 Feb;54(2):66-73. [Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M. ]
  102. Heterogeneous vancomycin-resistant Staphylococcus aureus (hetero-VISA) in Singapore. Int J Antimicrob Agents. 2005 Feb;25(2):177-9. [ Sng LH, Koh TH, Wang GC, Hsu LY, Kapi M, Hiramatsu K. ]
  103. Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus. J Bacteriol. 2005 Jun;187(11):3698-707. [ Watanabe S, Ito T, Takeuchi F, Endo M, Okuno E, Hiramatsu K. ]
  104. Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay. Emerg Infect Dis. 2005 Jun;11(6):973-6. [Ma XX, Galiana A, Pedreira W, Mowszowicz M, Christophersen I, Machiavello S, Lope L, Benaderet S, Buela F, Vincentino W, Albini M, Bertaux O, Constenla I, Bagnulo H, Llosa L, Ito T, Hiramatsu K. ]
  105. Dissemination of methicillin-resistant staphylococci among healthy Japanese children. J Clin Microbiol. 2005 Jul;43(7):3364-72. [ Hisata K, Kuwahara-Arai K, Yamanoto M, Ito T, Nakatomi Y, Cui L, Baba T, Terasawa M, Sotozono C, Kinoshita S, Yamashiro Y, Hiramatsu K. ]
  106. Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in a Turkish university hospital: brief report of a surveillance study. Int J Antimicrob Agents. 2005 Dec;26(6):508-10. [ Torun MM, Bahar H, Demirci M, Altas K, Bagdatli Y, Kocazeybek B, Kapi M, Hiramatsu K. ]
  107. Genetic differentiation of methicillin-resistant Staphylococcus aureus strains from Korea and Japan. Microb Drug Resist. 2005 Fall;11(3):279-86. [ Soo Ko K, Peck KR, Sup Oh W, Lee NY, Hiramatsu K, Song JH. ]
  108. Antibacterial activity of dipropofol and related compounds. Biol Pharm Bull. 2005 Jun;28(6):1120-2. [Ogata M, Tutumimoto Sato K, Kunikane T, Oka K, Seki M, Urano S, Hiramatsu K, Endo T. ]
  109. Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999. J Med Microbiol. 2005 Jun;54(Pt 6):557-65. [Noguchi N, Suwa J, Narui K, Sasatsu M, Ito T, Hiramatsu K, Song JH. ]
  110. DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus. Antimicrob Agents Chemother. 2005 Aug;49(8):3404-13. [Cui L, Lian JQ, Neoh HM, Reyes E, Hiramatsu K.]
  111. Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J Bacteriol. 2005 Nov;187(21):7292-308. [ Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K. ]
  112. Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2006 Feb;50(2):428-38. [ Cui L, Iwamoto A, Lian JQ, Neoh HM, Maruyama T, Horikawa Y, Hiramatsu K. ]
    [CLICK HERE] to see [Journal Highlights, March 2006, Microbe.] This paper has been selected for the Journal Highlights section of Microbe (formerly ASM News), to appear in the March 2006 issue.
  113. Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2006 Mar;50(3):1079-82. [Cui L, Tominaga E, Neoh HM, Hiramatsu K. ]
  114. Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 Asian countries: a proposal for a new nomenclature for SCCmec elements. Antimicrob Agents Chemother. 2006 Mar;50(3):1001-12. [ Chongtrakool P, Ito T, Ma XX, Kondo Y, Trakulsomboon S, Tiensasitorn C, Jamklang M, Chavalit T, Song JH, Hiramatsu K. ]
  115. Methicillin-Resistant Staphylococcus pseudintermedius in a Veterinary Teaching Hospital J Clin Microbiol.. 2007 April;45(4):1118-1125. [ Sasaki T, Kikuchi K, Tanaka Y, Takahashi N, Kamata S, Hiramatsu K. ]new!
  116. A novel in vitro pharmacokinetic/pharmacodynamic model based on two-compartment open model used to simulate serum drug concentration-time profiles. Microbiol Immunol. 2007;51(5):567-75. [ Tomita T, Ohara-Nemoto Y, Moriyama H, Ozawa A, Takeda Y, Kikuchi K. ]new!
  117. Reclassification of phenotypically-identified Staphylococcus intermedius strains. J Clin Microbiol.. JCM Accepts, published online ahead of print on 27 June 2007 [ Sasaki T, Kikuchi K, Tanaka Y, Takahashi N, Kamata S, Hiramatsu K. ]new!
  118. Precise excision and self-integration of a composite transposon as a model for spontaneous large-scale chromosome inversion/deletion of the Staphylococcus haemolyticus clinical strain JCSC1435. J Bacteriol. 2007 Apr;189(7):2921-5. [Watanabe S, Ito T, Morimoto Y, Takeuchi F, Hiramatsu K.]new!

Review Articles
  1. Molecular evolution of MRSA. . Microbiol. Immunol. 39: 531-543. 1995 [Hiramatsu, K.]
  2. Genetic basis for the molecular epidemiology of MRSA. J. Infect. Chemother. 2(3):117-129. 1996 [Hiramatsu, K., N. Kondo, and T. Ito.]
  3. Vancomycin resistance in staphylococci. Drug Res. Updates. 1:135-150. 1998 [Hiramatsu, K.]
  4. Acquisition of methicillin resistance and progression of multi-anitibiotic resistance in methicillin-resistant Staphylococcus aureus Yunsei Medical Journal on Antimicrobial Resistance. Dec;39(6):526-33. 1998 [Ito, T., and Hiramatsu, K]
  5. Detection method of glycopeptide-resistant Staphylococcus aureus. Methods in Molecular Medicine. vol 48. 85 - 91, 93 -101 1999. [Hanaki, H., and Hiramatsu, K.]
  6. The emergence and evolution of methicillin-resistant Staphylococcus aureus.Trends Microbiol. Oct;9(10):486-93. 2001 [Hiramatsu K, Cui L, Kuroda M, Ito T.]
  7. Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance.Lancet Infect Dis. Oct;1(3):147-55. 2001 [Hiramatsu K.]
  8. Vancomycin-resistant Staphylococcus aureus. A. C. Fluit and F. J. Schmitz (ed.) MRSA: Current Perspectives. p. 187-212. Caister Academic Press, Norfolk, England. [ Longzhu Cui and Keiichi Hiramatsu. ]
  9. Application of Genomic Information to the Diagnosis, Management and Control of Bacterial Infections: The Staphylococcus aureus model 2003, Diagnostic Molecular Microbiology 2nd Ed, pp407-418, ed.by D. Persing, et al., ASM Press [ Hiramatsu K, Kuroda M, Baba T, and Okuma K: ]
  10. Genetic characterization of methicillin-resistant Staphylococcus aureus Vaccine. 2004, Dec 6;22 Suppl 1:S5-8. [Hiramatsu K, Watanabe S, Takeuchi F, Ito T, and Baba T]
  11. The Genome of Staphylococcus aureus.  2004, Molecular and Clinical Aspects. pp66-153. Eliis Harwood, London, UK. ed.by Al'Aladeen D, and Hiramatsu K. [ Baba T,Takeuchi F, Kuroda M, Yuzawa H, Ito T, and Hiramatsu K: ]
  12. Genome sequencing and annotation: an overview 2004, Series. Methods Mol Biol. Chapter 2. 266:29-45. Genomics, Proteomics and Clinical Bacteriology. Humana Press, ed. by Johnson, A., and Woodford, N [ Kuroda M, and Hiramatsu K: ]
  13. Has vancomycin-resistant Staphylococcus aureus started going it alone? Lancet. 2004 Aug 14-20;364(9434):565-6. [ Hiramatsu K, Cui L, Kuwahara-Arai K. ]new!
  14. Advance in vancomycin-resistance research in Staphylococcus aureus 2005, Frontiers in Antimicrobial Resistance: a Tribute to Stuart B. Levy ; Editors: Alekshun M, McDermott P, and White D. Chapt 21, p289-298. August. [ Hiramatsu K, Kapi M, Tajima Y, Cui L, Trakulsomboon S, and Ito T.]new!